Silica solid microneedle arrays with different needle heights and densities were manufactured. These microneedle arrays were used to puncture the human cadaver skin. After the pretreatment, the electric resistance of the skin and the flux of a water soluble drug across the skin were measured. A linear correlation between the drug flux and the inverse of the skin electric resistance was observed. Taller microneedle arrays were more effective in creating pathways across skin and enhancing drug flux, but the needle density was less important in enhancing drug flux at sufficient needle heights.
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