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Evaluation of In-Vitro Release Properties of Vancomycin Microspheres Prepared with Polyaspartic Acid

机译:用聚天冬氨酸制备的万古霉素微球的体外释放性能评价

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The biodegradable polyaminoacid microspheres containing vancomycin hydrochloride (VANCO) were prepared by the solvent evaporation method with different polymer:drug ratios (1:1, 2:1, 3:1 and 4:1). The encapsulation efficiency and the in vitro release characteristics of the drug-loaded microspheres were studied. Results show that the microsphere formulations have shown sustained-release effect.
机译:通过溶剂蒸发法,以不同的聚合物:药物比(1:1、2:1、3:1和4:1)制备了含有万古霉素盐酸盐(VANCO)的可生物降解的聚氨基酸微球。研究了载药微球的包封率和体外释放特性。结果表明,微球制剂具有缓释作用。

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