Polymer MW determines nanocarrier characteristics to reveal an ideal vehicle for targeted enzyme delivery

摘要

Biodegradable polymer nanocarrier (PNC) enzyme encapsulation can improve drug delivery by protecting cargo from proteolysis. Chemistry and MW of PNC-constituent amphiphilic polymer determines PNC morphology and degradation. We studied MW influences on PNC synthesis, loading and stability. Carriers with superior enzyme loading and protection may prolong drug effects in vivo.