POLY (ETHYLENE OXIDE)-POLY(ε-CAPROLACTONE) MICELLES IN DIFFERENT MORPHOLOGIES: ADVANTAGES OF WORM-LIKE MICELLES FOR DELIVERY OF PACLITAXEL IN LUNG CANCER THERAPY

摘要

Worm-like polymeric micelles were formed from PEO-PCL diblock polymer and showed advantages over conventional spherical micelles regarding drug loading capacity. Subsequent animal studies further highlighted worm-like micelles with respect to the enhanced MTD, improved tumor shrinkage effect, and reduced toxicity to non-tumor organs.