Temperature-controlled Intracellular Localization of Thermoresponsive Polymeric Micelles

摘要

We have designed outermost fluorescence-labeled polymeric micelles via multi-assembling of amphiphilic block copolymers comprising thermoresponsive polymer segments with terminal functionalities and biodegradable polymer segments. In this study, we have successfully controlled cellular uptakes of the micelles by temperature modulation across the lower critical solution temperature (LCST).