Effective G-CSF Site Directed PEGylation of Hindered Aminoacids

机译：受阻氨基酸的有效G-CSF定点PEG化

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A new alkyl maleimido activated monomethoxypoly(ethylene glycol) (PEG-C_(18)-Mal) for site-directed protein conjugation was synthesised and characterized. As compared to the commercial mPEG-maleimido, PEG-C_(18)-Mal was more efficient in the bioconjugation to ~(17)Cys of rh-G-CSF in guanidinium free buffer and gave more stable bioconjugate. Also, the new bioconjugate displayed high biological activity.

机译：合成并表征了一种新的烷基马来酰亚胺基活化的单甲氧基聚乙二醇（PEG-C_（18）-Mal）。与市售的mPEG-马来酰亚胺基相比，PEG-C_（18）-Mal在无胍的缓冲液中与rh-G-CSF的〜（17）Cys生物缀合更有效，并提供了更稳定的生物缀合物。而且，新的生物结合物显示出高的生物活性。

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《Controlled Release Society Annual Meeting and Exposition》|2007年|P.370-371|共2页
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Stefano Salmaso; Mauro Sergi; Anna Scomparin; Sara Bersani; Rodolfo Schrepfer; Giancarlo Tonon; Paolo Caliceti;
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中图分类生物工程学（生物技术）;
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入库时间 2022-08-26 14:56:38

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1. Site-Specific Pegylation of G-CSF by Reversible Denaturation [J] . Francesco M.Veronese, Anna Mero, Francesca Caboi Bioconjugate Chemistry . 2007,第6期

机译：可逆变性通过G-CSF进行位点特异性聚乙二醇化
2. Site-Directed Pegylation at Specific Sites Significantly Prolongs the Half-Life of A1A2A3-VWF By Markedly Attenuating LRP1-Mediated Clearance [J] . OSullivan Jamie M., Fazavana Judicael, Chan Alain, Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：通过显着衰减LRP1介导的间隙，特定部位的定向聚乙二醇明显延长A1A2A3-VWF的半衰期
3. Site Directed Disulfide PEGylation of Interferon-beta-1b with Fork Peptide Linker [J] . Abbasi Shayan, Farahani Homa, Lanjanian Hossein, Bioconjugate Chemistry . 2020,第3期

机译：存在于叉肽接头的干扰素-β1b的网站定向二硫化物pegymation
4. Effective G-CSF Site Directed PEGylation of Hindered Aminoacids [C] . Stefano Salmaso, Mauro Sergi, Anna Scomparin, Controlled Release Society Annual Meeting and Exposition . 2007

机译：有效的G-CSF位点定向受阻氨基酸的聚乙二醇化
5. Site-directed ligand discovery for allosteric sites and protein-protein interfaces [D] . Rettenmaier, Terry Justin 2015

机译：定点配体的变构位点和蛋白质-蛋白质界面的发现
6. Synthesis of the Bacteriostatic Poly(l-Lactide) by Using Zinc (II)(acac)(L)H2O (L = Aminoacid-Based Chelate Ligands) as an Effective ROP Initiator [O] . Renata Barczyńska-Felusiak, Małgorzata Pastusiak, Piotr Rychter, 2021

机译：用锌（II）（ACAC）（L）H 2 O（L =氨基酸基螯合配体）作为有效ROP引发剂的合成抑菌聚（L-丙交酯）
7. Site-selective enzymatic chemistry for polymer conjugation to protein lysine residues: PEGylation of G-CSF at lysine-41 [O] . Mero, A., Grigoletto, A., Maso, K., 2016

机译：聚合物与蛋白赖氨酸残基结合的定点酶化学：G-CSF在赖氨酸41处的聚乙二醇化

Effective G-CSF Site Directed PEGylation of Hindered Aminoacids

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