Nanocarrier Formulation of a Geldanamycin Prodrug in ABC Micelles: Pharmacokinetics and Tolerability in Rats

机译：Geldanamycin前体药物在ABC胶束中的纳米载体制剂：大鼠的药代动力学和耐受性

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A Cremophor~R-free formulation of a geldanamycin prodrug was prepared using amphiphilic block co-polymer micelles of poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-b-PCL). Rats were dosed intravenously with PEG-b-PGL micelles and DMAG as control. The area under the curve, mean residence time, and tolerability increased. Total clearance, volume of distribution, and nonspecific systemic exposure decreased.

机译：使用聚（乙二醇）-b-聚（ε-己内酯）（PEG-b-PCL）的两亲嵌段共聚物胶束，制备了不含克雷莫尔的格尔德霉素前药制剂。给大鼠静脉内注射PEG-b-PGL胶束和DMAG作为对照。曲线下的面积，平均停留时间和耐受性增加。总清除率，分布量和非特异性全身暴露均下降。

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《Controlled Release Society Annual Meeting and Exposition》|2007年|P.458-459|共2页
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M. Laird Forrest; Jaime A. Yanez; Connie M. Remsberg; Glen S. Kwon; Neal M. Davies;
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中图分类生物工程学（生物技术）;
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1. Formulation of a geldanamycin prodrug in mPEG-b-PCL micelles greatly enhances tolerability and pharmacokinetics in rats [J] . Xiong MP, Yanez JA, Remsberg CM, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2008,第1期

机译：在mPEG-b-PCL胶束中配制格尔德霉素前药可大大增强大鼠的耐受性和药代动力学
2. Paclitaxel Prodrugs with Sustained Release and High Solubility in Poly(ethylene glycol)-b-poly(ε-caprolactone) Micelle Nanocarriers: Pharmacokinetic Disposition, Tolerability, and Cytotoxicity [J] . M. Laird Forrest, Jaime A. Yá?ez, Connie M. Remsberg, Pharmaceutical Research . 2008,第1期

机译：在聚（乙二醇）-b-聚（ε-己内酯）胶束纳米载体中具有持续释放和高溶解度的紫杉醇前药：药代动力学处置，耐受性和细胞毒性
3. Paclitaxel prodrugs with sustained release and high solubility in poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelle nanocarriers: pharmacokinetic disposition, tolerability, and cytotoxicity. [J] . Forrest ML, Yanez JA, Remsberg CM, Pharmaceutical research . 2008,第1期

机译：紫杉醇前药具有持续释放和高溶解度在聚（乙二醇）-B-聚（ε-己内酯）胶束载体：药代动力学置换，耐受性和细胞毒性。
4. Nanocarrier Formulation of a Geldanamycin Prodrug in ABC Micelles: Pharmacokinetics and Tolerability in Rats [C] . M. Laird Forrest, Jaime A. Yanez, Connie M. Remsberg, Controlled Release Society Annual Meeting and Exposition . 2007

机译：ABC胶束中Geldanamycin前药的纳米载体制剂：大鼠药代动力学和耐受性
5. Evaluation of a phosphoryloxymethyl (POM) prodrug of camptothecin: Preformulation, formulation and pharmacokinetic studies. [D] . Hanson, Bradley Allen. 2002

机译：喜树碱的磷酰氧基甲基（POM）前药的评估：配制，制剂和药代动力学研究。
6. Formulation of a Geldanamycin Prodrug in mPEG-b-PCL Micelles Greatly Enhances Tolerability and Pharmacokinetics in Rats [O] . May P. Xiong, Jaime A. Yáñez, Connie M. Remsberg, -1

机译：在mPEG-b-PCL胶束中配制格尔德霉素前药可大大增强大鼠的耐受性和药代动力学
7. Formulation of a geldanamycin prodrug in mPEG-b-PCL micelles greatly enhances tolerability and pharmacokinetics in rats [O] . May P. Xiong, Jaime A. Yáñez, Connie M. Remsberg, 2008

机译：MPEG-B-PCL胶束中的Geldanamycin前药的制剂大大提高了大鼠的耐受性和药代动力学

Nanocarrier Formulation of a Geldanamycin Prodrug in ABC Micelles: Pharmacokinetics and Tolerability in Rats

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