Design and Studies of Novel Ophthalmic Inserts for Extended Release of Gatifloxacin

摘要

Objective of this study is to design extendedrelease ophthalmic inserts of gatifloxacin, anantibacterial drug, using Polyethyleneoxide (PEO),hydroxypropylmethylcellulose (HPMC) andmethacralyte copolymers (Eudragit) in differentcombinations and to evaluate their physicalproperties and in-vitro release characteristics. Inbest formulations in vitro release was extended up to12 hrs.