A Prospective Cohort Study on Vegetable and Garotenoid Consumption and Lung Cancer Risk in Yunnan Tin Miners

摘要

The association between vegetable and carotenoid consumption and lung cancer risk was investigated in the YTC cohort study among 10,170 tin miners aged more than 40 years at the start in March 1992. Analyses were based on 300 incident lung cancer cases and 7665 subcohort members after 5 years of follow-up. The results showed that There are significantly positive association between the consumption of β-carotene, α-carotene, lutein+zeaxanthin, lycopene calculated by using the American database and the consumption of β-carotene and retinol equivalent calculated by using the Chinese Food Composition(p < 0.01); there are different intakes of vegetables and carotenoids between lung cancer cases and the subcohort members (p < 0.01); subcohort members consumed significantly more total vegetables, Cruciferous vegetables, celery, radish roots, yams, alliums, melons and β-carotene, α-carotene than did cases(p < 0.01); there is significantly different incidence of lung cancer in the consumption of total vegetable, radish roots,alliums, celery, Cruciferous vegetables, yams, melons(e.g Wax gourd,pumpkins et al), bean sprouts and α-carotene, α-carotene(p < 0.01); there are moderate or weak inverse association between lung cancer and the consumption of total vegetable, radish roots, alliums, celery, Cruciferous vegetables, yams, melons, bean sprouts and β-carotene, α-carotene;(RR=0.5～0.75, p < 0.05) after age- and multivariable-adjusted Cox regression model. Multivariable adjusted relative risk(RR) after adjustment for age, smoking status, occupational exposure and alcohol intake for the lowest to highest quartiles of cruciferous vegetables were 1.00,0.81,0.97,0.69(p for trend=0.11).For celery, the corresponding values were 1.00,1.01,0.92, 0.73 (p trend=0.20), for radish root, 1.00, 0.78,0.92, 0.67 (p trend=0.09), for yam et al, 1.00,0.93, 0.68,0.68(p trend=0.02). for α-carotenoid, 1.00,0.82,0.85 and 0.56(p trend=0.001).Therefore, This prospective study suggests that vegetable and carotenoid consumption especially celery,yam, cruciferous vegetable alliums and α-carotene can decrease the incidence of lung cancer in YTC miners.