首页> 外文会议>Proceedings of the 29th Annual Meeting of the Controlled Release Society >REGIONAL AND DIET DEPENDENT OF DRUG ABSORPTION AND GENE EXPRESSION BY GENECHIP ANALYSIS IN RAT
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REGIONAL AND DIET DEPENDENT OF DRUG ABSORPTION AND GENE EXPRESSION BY GENECHIP ANALYSIS IN RAT

机译:基因表达谱分析大鼠药物吸收和基因表达的区域和饮食依赖性

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摘要

The purpose of this research is to study regional and diet dependent of drug absorption and gene expression using GeneChip analysis. Prodrug valacyclovir showed higher intestinal permeability than parent drug acyclovir. High protein diet significantly decreased valacylcovir permeability. The gene expression profiles showed dramatic difference in different regions of intestine.
机译:这项研究的目的是使用GeneChip分析研究区域和饮食依赖药物吸收和基因表达的情况。前药伐昔洛韦比母体药物阿昔洛韦显示更高的肠通透性。高蛋白饮食会显着降低valacylcovir的通透性。基因表达谱在肠的不同区域显示出显着差异。

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