Buccoadhesive tablets of lignocaine hydrochlride, each containing 15 mg of lignocaine HC1, using various Carbopol-974 P (CP-974P) polymer combinations with HPMC-K4 M, SCMC (DVP), sodium alginate, Guar gum, HPC-M, Eudragit RS-100 and Eudragit NE -30 in different ratios were prepared. The tablets were subjected to in-vitro dissolution rate studies, in-vitro permeation studies, in-situ release studies and invitro swelling studies. The polymer combination of CP-974 P & SCMC (DVP) released almost 75.92% over 6 hours, greater than the other polymers combinations, in invitro release studies. The surface pH and bioadhesive strength of this formulation was also satisfactory. Total time of adhesion ideally desired was achieved. In-situ release studies revealed that the drug concentration remained well above the MEC, within the therapeutic range period of 6 hours.
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机译：盐酸利诺卡因的含糖胶粘剂片剂，每片含15 mg利诺卡因HCl，使用各种Carbopol-974 P（CP-974P）聚合物与HPMC-K4 M，SCMC（DVP），藻酸钠，瓜尔胶，HPC-M，Eudragit RS组合制备了不同比例的-100和Eudragit NE -30。对片剂进行体外溶出速率研究，体外渗透研究，原位释放研究和体外溶胀研究。在体外释放研究中，CP-974 P＆SCMC（DVP）的聚合物组合在6小时内释放了近75.92％，高于其他聚合物组合。该制剂的表面pH和生物粘附强度也令人满意。达到了理想的粘合总时间。原位释放研究表明，在6小时的治疗范围内，药物浓度仍远高于MEC。
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