BLOCK COPOLYMER MICELLES WITH HYBRID CORE OF CALCIUM PHOSPHATE AND ANTISENSE DNA AS NOVEL VECTOR SYSTEMS FOR DNA DELIVERY

摘要

Block copolymer micelles with the hybrid core of calcium phosphate and oligonucleotides (ODN) have been developed as a novel vector system for antisense therapy. The enhancement of the cellular uptake of ODN was observed through incorporation into the hybrid micelles.