Gamma scintigraphy can be applied to virtually all oral modified-release technologies and assists decision making during product development. Studies may be used to: 1. Visualize product performance in vivo 2. Focus the development strategy by providing early proof of concept data in man 3. Explore the mechanism of food effects 4. Demonstrate to regulatory authorities that the product is performing to its proposed rationale 5. Account for inter-subject variability in pharmacokinetic data 6. Overcome the poor predictability of in vitro studies for oral MR drug delivery systems.
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