BIOEFFECTS EVALUATION OF A LONG-TERM ADMINISTERING ChangLe BY ~1H NMR SPECTROSCOPY

摘要

Biological NMR spectroscopy has brought new chemistry into life science and clinical medicine with the advent of a generation of high field Fourier transform NMR spectrometers with increased sensitivity, chemical shift dispersion, resolution, dynamic range and improved computing capabilities. In recent years, high resolution NMR has been used for clinical diagnosis of abnormal metabolism of the inborn disease and investigation of toxicological and pharmacological effects of drugs. In the present study, we applied high-resolution ~1H NMR and other methods to study toxicological effects of ChangLe (a kind of rare earth complex applied in agriculture).