THE MOLECULAR DYNAMICS STUDY FOR DETECTION OF SSDNA BY MONOLAYER GRAPHENE NANOPORE

摘要

Molecular dynamics simulations are performed to provide valuable information about the translocation of four single-stranded DNAs with ten identical bases through graphene nanopore with diameter of 2 nm. The monolayer graphene nanopore is highly sensitive to ssDNA translocation events and the 10-base resolution detection can be realized by electrophoreticly threading ssDNA through graphene nanopore. Due to the similar sizes of the four nucleotides, the blockage current is unlikely to provide a distinguishable signal. However, by simply monitoring and analyzing the translocation time of poly(dA)_(10), poly(dC)_(10), poly(dG)_(10) and poly(dT)_(10) though graphene pore, each ssDNA can be identified and characterized.