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Preliminary studies on the use of modulation sensing for noninvasive monitoring of drug compliance

机译:对药物依从性非侵入性监测使用调制感应的初步研究

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Presently two methods in concert, a marker method and an electronic monitoring method, have been emphasized for an objective monitoring of drug compliance in ambulatory care. While the marker method proves dose ingestion, the electronic monitoring method provides continuous record of timing of presumptive drug doses. The marker method is however time intensive with associated safety problems, and the electronic monitoring method is easily defeated. We here present preliminary results on modulation sensing, a new method that could be used to non-invasively monitor patient compliance. Measurement is based on observing the amplitude modulation of the emission from both a short lifetime marker fluorophore of interest and a long lifetime reference fluorophore contained in the monitoring device. At some intermediate frequencies, the observed modulation of the combined emission is nearly equivalent to the fractional intensity of the marker fluorophore. This method precludes problems associated with measuring fluorescence intensities in highly scattering media. Using this method we measured the presence of rhodamine 800 (Rh800) in intralipid suspensions and chicken tissue. Rh800 is excited at long wavelengths not absorbed by tissues. Micromolar concentrations of this dye were detected in intralipid and chicken muscle covered with a layer of chicken skin.
机译:目前,在音乐会,标记方法和电子监测方法中,已经强调用于客观监测手术护理的药物依从性。虽然标记方法证明剂量摄入,但电子监测方法提供了推定药物剂量的时间的连续记录。然而,标记方法与相关的安全问题有时间密集,电子监测方法很容易击败。我们在这里提出初步结果对调制感测,这是一种可用于非侵入性监测患者依从性的新方法。测量是基于观察来自感兴趣的短寿命标记荧光团的发射的幅度调节以及监测装置中包含的长寿命参考荧光团。在一些中间频率下,所观察到的组合发射的调节几乎相当于标记荧光团的分数强度。该方法妨碍了与测量高度散射介质中的荧光强度相关的问题。使用该方法,我们测量了荨麻糖悬浮液和鸡组织中的罗丹明800(RH800)的存在。 RH800在不被组织吸收的长波长下兴奋。在intralipid和用一层鸡皮覆盖的鸡肉肌中检测到这种染料的微摩尔浓度。

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