Study of Correlation between Hippocampus's Texture and Morphological Features in Alzheimer's Disease Patients Based on MR Image

摘要

Alzheimer's disease (AD) is a degenerative pathological change of the nervous system. It has been reported in the literature that there are 18 million patients in the world and as high as 4.8 percent people suffering from AD in China among those over the age of sixty-five. Early diagnosis of AD is very difficult. In this study, gray level co-occurrence matrix was used to investigate the texture features in the hippocampus of AD patients based on MR image. Then the correlation between texture features and traditional morphological features as well as clinical cognitive function were tested. The results indicated that the features on texture may be more sensitive than that on morphology in reflecting pathological changes of AD. In the mean time, it could provide new evidence on early diagnosis of AD.