Optimization of Hydroxyapatite Particles labeling with Samarium-153 as a Therapeutic Agent for Radiation Synovectomy

摘要

Hydroxyapatite (HA) was studied as a particulate carrier for beta-emitting radionuclides in radiation synovectomy. Particles were labeled with ~(153)Sm (T_(1/2) = 1.95 days, beta-energy = 810 (20percent), 710 (50percent), 640 (30percent) keV, gamma-energy = 103.2 (29.8percent) keV, range of beta particles in tissue is 2.5 mm). Labeling efficiency was greater than 95percent at pH 4-6. The compound is sterile and pyrogen free with its stability of 6 days. In vivo studies by intra-articular injection into the knee joints of normal rats showed the total cumulative leakage of ~(153)Sm over 6 days was around 2 percentage injected dose (ID). The ease of preparation of ~(153)Sm-HA, the high efficiency of labeling and low leakage from the joint make ~(153)Sm-HA attractive for radiation synovectomy.