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Monitoring changes of viscoelasticity during blood coagulation with acoustic sensors

机译:使用声学传感器监测凝血过程中的粘弹性变化

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In our previous work we demonstrated the general suitability of surface and bulk acoustic wave (SAW and BAW) structures for recording the continuous change of fluidic behavior in the course of blood coagulation processes [1]. Special advantage can be taken from the direct impact of fluid consistence on SAW and BAW device parameters (e.g. resonator frequency, quality factor, impedance). Beside the ability of continuous detection of coagulation process further tests can be realized with SAW and BAW devices as was shown in an acoustic version of thrombelastography [2]. In this paper, we make the proposal to describe the observed features of blood in the frame of non-Newtonian behavior. Therefore we distinguish between acoustic monitoring of shear viscosity and shear elasticity changes during the whole process of haemostasis. The goal is to get more detailed insight into the ongoing biological process. That approach is suggested from modeling of resonance-antiresonance behavior of thickness shear-mode resonators (TSM), also called quartz crystal microbalance (QCM). The response of resonance and antiresonance parameters can be significantly different from each other, depending on the shear viscosity and elasticity of the loaded fluid. For example, the frequency shifts of both resonances have the same or the opposite sign when changing the viscosity or the elasticity, respectively. The results of modeling the QCM response to viscoelastic loading are used for the interpretation of time dependent measurement signals of the coagulation process.
机译:在我们以前的工作中,我们证明了表面和体声波(SAW和BAW)结构通常适用于记录血液凝固过程中流体行为的连续变化[1]。流体稠度对SAW和BAW设备参数(例如谐振器频率,品质因数,阻抗)的直接影响可以带来特别的好处。除了可以连续检测凝血过程的能力以外,还可以使用声表面血栓弹性成像技术显示的SAW和BAW设备进行进一步测试[2]。在本文中,我们提出了在非牛顿行为框架内描述观察到的血液特征的建议。因此,我们在止血的整个过程中,分别对剪切粘度和剪切弹性变化进行声学监测。目的是更深入地了解正在进行的生物过程。从厚度剪切模式谐振器(TSM),也称为石英晶体微天平(QCM)的谐振-反谐振行为的建模中建议了这种方法。共振和反共振参数的响应可能会彼此显着不同,具体取决于剪切流体的剪切粘度和弹性。例如,当改变粘度或弹性时,两个共振的频移分别具有相同或相反的符号。 QCM对粘弹性载荷响应建模的结果用于解释凝血过程的时间相关测量信号。

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