Broad-band neck suction in the assessment of the dynamics of the baroreflex-heart rate transfer in humans

摘要

In this study we applied broad-band neck suction (NES) stimulation to 11 healthy individuals and 10 chronic heart failure (CHF) patients, and performed a closed-loop estimation of the transfer magnitude characteristics (gain) of the carotid sinus baroreceptor-RR interval (RRI) reflex using a non-parametric frequency domain approach. The suction pressure, obtained through a servo-controlled pump, was 0/spl divide/-35 mmHg in the band 0/spl divide/0.35 Hz. We found a marked difference in the pattern of the gain between the two groups. Particularly, normal subjects showed a band-pass behavior centered at 0.1/spl plusmn/0.01 Hz, whereas CHF patients showed a marked low-pass response in the VLF band with a progressive attenuation in the LF and HF bands. The coherence between NES and RRI was typically >0.5, which would imply a low precision of gain point estimates.