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Effect of flow on prostaglandin E/sub 2/ production and inositol trisphosphate levels in cultured osteoblasts

机译：流量对培养成骨细胞中前列腺素E / sub 2 /产生和三磷酸肌醇水平的影响

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In order to determine what effects flow has on prostaglandin production, prostaglandin E/sub 2/ levels were analyzed in perfusing media. To examine the effect of flow on cultured osteoblasts, intracellular concentrations of inositol trisphosphate were measured. It is shown that prostaglandin E/sub 2/ production is increased in cells exposed to either steady or pulsatile flow. Flow-caused oscillations were observed in the intracellular levels of inositol trisphosphate. These responses are both shear and time dependent.

机译：为了确定血流对前列腺素产生的影响，在灌注培养基中分析了前列腺素E / sub 2 /水平。为了检查血流对培养的成骨细胞的影响，测量了胞内三磷酸肌醇浓度。结果表明，暴露于稳定或脉动流的细胞中前列腺素E / sub 2 /的产量增加。在细胞内三磷酸肌醇水平上观察到由流动引起的振荡。这些响应与剪切和时间有关。

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《》|1990年|P.152-153|共2页
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Reich; K.M.; Gay; C.V.;
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中图分类无线电电子学、电信技术;
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1. Sperm-induced Ca2+ oscillations in mouse oocytes and eggs can be mimicked by photolysis of caged inositol 1,4,5-trisphosphate: Evidence to support a continuous low level production of inositol 1,4,5-trisphosphate during mammalian fertilization [J] . Jones KT., Nixon VL. Developmental biology . 2000,第1期

机译：笼状肌醇1,4,5-三磷酸的光解可以模拟小鼠卵母细胞和卵子中精子诱导的Ca2 +振荡：在哺乳动物受精过程中支持持续低水平生产肌醇1,4,5-三磷酸的证据。
2. Sperm-Induced Ca2+ Oscillations in Mouse Oocytes and Eggs Can Be Mimicked by Photolysis of Caged Inositol 1,4,5-Trisphosphate: Evidence to Support a Continuous Low Level Production of Inositol 1,4,5-Trisphosphate during Mammalian Fertilization [J] . Keith T. Jones, Victoria L. Nixon Developmental biology . 2000,第1期

机译：笼中肌醇1,4,5-三磷酸的光解可以模仿小鼠卵母细胞和卵中精子诱导的Ca 2+振荡：支持哺乳动物受精过程中持续低水平生产肌醇1,4,5-三磷酸的证据。
3. Induction of differentiation in v-Ha-ras-transformed MDCK cells by prostaglandin E2 and 8-bromo-cyclic AMP is associated with a decrease in steady-state level of inositol 1,4,5-trisphosphate. [J] . Y Y Wu, M C Lin Molecular and Cellular Biology . 1990,第1期

机译：前列腺素E2和8-溴环AMP在v-Ha-ras转化的MDCK细胞中诱导分化与肌醇1,4,5-三磷酸肌醇稳态水平降低有关。
4. Effect of flow on prostaglandin E/sub 2/ production and inositol trisphosphate levels in cultured osteoblasts [C] . Reich, K.M., Gay, . 1990

机译：流量对培养成骨细胞中前列腺素E / sub 2 /产生和三磷酸肌醇水平的影响
5. Unique Regulatory Properties of Heterotetrameric Inositol 1,4,5-trisphosphate Receptors Revealed by Studying Concatenated Receptor Constructs. [D] . Chandrasekhar, Rahul. 2016

机译：通过研究级联受体构建体揭示了异四聚肌醇1,4,5-三磷酸受体的独特调控特性。
6. Induction of differentiation in v-Ha-ras-transformed MDCK cells by prostaglandin E2 and 8-bromo-cyclic AMP is associated with a decrease in steady-state level of inositol 145-trisphosphate. [O] . Y Y Wu, M C Lin 1990

机译：前列腺素E2和8-溴环AMP在v-Ha-ras转化的MDCK细胞中诱导分化与肌醇145-三磷酸肌醇稳态水平降低有关。
7. Sperm-induced Ca²⁺ oscillations in mouse oocytes and eggs can be mimicked by photolysis of caged inositol 1,4,5-trisphosphate: evidence to support a continuous low level production of inositol 1,4,5-trisphosphate during mammalian fertilization [O] . Jones, Keith T., Nixon, Victoria L. 2000

机译：笼养的1,4,5-三磷酸肌醇的光解可以模拟小鼠卵母细胞和卵子中精子诱导的Ca 2+振荡：在哺乳动物受精过程中支持持续低水平生产1,4,5-三磷酸肌醇的证据
8. Effect of Prostaglandins, Inositol 1,4,5-Trisphosphate, and Phorbol Esters onRadiation-Induced Decreases in Calcium Influx in Rat Brain Synaptosomes [R] . Kandasamy, S. B., Harris, A. H. 1992

机译：前列腺素，肌醇1,4,5-三磷酸酯和佛波酯对大鼠脑突触体中钙离子流量减少的影响

Effect of flow on prostaglandin E/sub 2/ production and inositol trisphosphate levels in cultured osteoblasts

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