SYNTHESIS, CHARACTERIZATION AND BIODEGRADATION OF FUNCTIONALIZED POLY(ESTER AMIDE)S

摘要

@@Absorbable polyesters like polyglycolide, polylactides, poly-e-caprolactone and their copolymers have found a wide range of applications, such as sutures, bone fracture fixation devices, drug controlled release carriers because of their biodegradability and biocompatibility.1 However, their further potential applications are limited by the lack of functionality along the polyester backbone chains. Polyamides have excellent mechanical and processing properties in comparison with polyesters, and moreover, they could be easily modified. Therefore, the combination of these two classes of polymers would produce a new family of polymeric materials, poly(ester amide)s (PEAs), PEAs have both ester and amide blocks on their backbones and are regarded as promising biodegradable materials, as they combined good mechanical, thermal and processing properties of polyamides and the biodegradability of polyesters.