DESIGN OF NEW CONTROLLED DRUG RELEASE MICRO-CARRIERS BASED ON MEMS AND STUDY OF ITS DRUG RELEASE TRAITS

摘要

The objective of this work is to design and fabricate a novel poly(lactic-co-glycolic acid)(PLGA) biodegradable carrier with multi-chambers by solvent-casting technique on a poly(dimethylsiloxane)(PDMS) mold, for controlled drug release system. Three types of PLGA films, as follow single PLGA film, multiple molar ratios PLGA mixed film and porous film, are fabricated to encapsulate the carriers loading with paracetamol, a conventional low molecular weight water-soluble drug. After the carriers encapsulated to form three kinds of capsules, we study the capsules in vitro tests to evaluate the kinetics of drug release. The results show that the capsules can't achieve sustained drug release only by diffusion, but the carriers with porous film have realized preferable linear release of sample representing a suitable dosage form for implantable long-term controlled drug release system.