Biomarkers and Molecular Epidemiological Study and Occupational Health: Conception and Practices

摘要

Research on genetic susceptibility biomarkers can provide a molecular basis for interindividual variations in metabolizing drugs and toxic chemicals. In addition to this mechanistic information, the studies hold great promise in identifying chemicals susceptible to individuals and protecting them from environmental toxicity, particularly useful in preventing chemical from occupational exposure. Recently, research activities in this field are enlarged rapidly. However, we are facing the following challenges. Firstly, most of the effects have been focused on the association of gene and cancer endpoints, whereas less on gene and the biomarkers of exposure and early effects. Secondary, case-control design is commonly used for examining the interaction of genetic susceptibility markers and environmental exposures. The most ideal design is cohort study, since it can overcome the deficiencies encountered in case-control studies. To explore the genetic susceptibility biomarkers, we can follow up a cohort and detect the exposed carcinogen level and assay some muti-stage endpoints before the appearance of chemical induced cancer in occupational exposed population.