GDNF-RELEASING BIODEGRADABLE MICROSPHERES PROMOTE STRIATAL REINNERVATION, AND FUNCTIONAL RECOVERY IN A RAT MODEL OF PARKINSON'S DISEASE

机译：GDNF释放的生物可降解微球促进帕金森病大鼠模型的神经再生和功能恢复

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Intracerebral delivery of glial cell-line derived neurotrophic factor by poly(lactic acid-co-glycolic acid) microspheres was evaluated in a rat model of Parkinson's disease. This study showed a significant behavioral improvement of the rats due to the sprouting of the surviving dopaminergic fibers toward the implanted microspheres.

机译：在帕金森氏病的大鼠模型中评估了由聚乳酸-乙醇酸共聚物微球在脑内递送神经胶质细胞系衍生的神经营养因子。这项研究表明，由于存活的多巴胺能纤维向植入的微球发芽，大鼠的行为有了显着改善。

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来源
《International symposium on controlled release of bioactive materials;Consumer diversified products conference》|2001年|p.991-992|共2页
会议地点 San Diego CA(US);San Diego CA(US)
作者
C. Jollivet; A. Clavreul; M.C. Venier; A. Poueessel; P. Brachet; C. Montero-Menei; J.P. Benoit; P. Menei;
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INSERM ERIT-M 0104 'Ingenieurie de la vectorisation particulaire' 10 rue A Bocquel 49100 Angers France;

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GDNF; neurotrophic factors; microspheres; Parkinson's disease; poly(lactic acid-co-glycolic acid);

机译：GDNF；神经营养因子；微球帕金森氏病；聚乳酸-乙醇酸;

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专利

1. Striatal implantation of GDNF releasing biodegradable microspheres promotes recovery of motor function in a partial model of Parkinson's disease. [J] . Jollivet C, Aubert Pouessel A, Clavreul A, Biomaterials . 2004,第5期

机译：GDNF的纹状体植入可释放可生物降解的微球，从而在帕金森氏病的部分模型中促进运动功能的恢复。
2. Striatal implantation of GDNF releasing biodegradable microspheres promotes recovery of motor function in a partial model of Parkinson's disease. [J] . Jollivet C, Aubert Pouessel A, Clavreul A, Biomaterials . 2004,第5期

机译：GDNF的纹状体植入可释放可生物降解的微球，从而在帕金森氏病的部分模型中促进运动功能的恢复。
3. In vivo administration of VEGF- and GDNF-releasing biodegradable polymeric microspheres in a severe lesion model of Parkinson's disease [J] . HerránE., Ruiz-OrtegaJ.á., AristietaA., European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2013,第3aPta2期

机译：在帕金森氏病的严重病变模型中体内施用释放VEGF和GDNF的生物可降解聚合物微球
4. Using wavelet analysis to reveal the muscle functional recovery following nerve reinnervation in a rat model [C] . Zhou Hui, Yang Lin, Zhang Liangqing, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2014

机译：使用小波分析揭示大鼠神经再支配后的肌肉功能恢复
5. Striatal Neurons in the Development of Levodopa-Induced Dyskinesias in Parkinson's Disease [D] . Alberico, Stephanie Lorraine. 2017

机译：帕金森氏病中左多巴诱导的运动障碍发展中的纹状体神经元
6. Influence of cell preparation and target location on the behavioral recovery after striatal transplantation of fetal dopaminergic neurons in a primate model of Parkinsons disease [O] . D. E. Redmond Jr, A Vinuela, J. H. Kordower, -1

机译：在帕金森氏病灵长类动物模型中胎儿多巴胺能神经元的纹状体移植后细胞制备和靶标位置对行为恢复的影响
7. Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease [O] . L Wang, S Muramatsu, Y Lu, 2002

机译：AAV-GDNF的延迟递送可防止千兆神经变性，促进帕金森病的大鼠模型中的功能恢复

GDNF-RELEASING BIODEGRADABLE MICROSPHERES PROMOTE STRIATAL REINNERVATION, AND FUNCTIONAL RECOVERY IN A RAT MODEL OF PARKINSON'S DISEASE

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