Sketching Algorithms for Genomic Data Analysis and Querying in a Secure Enclave

摘要

Current practices in collaborative genomic data analysis (e.g. PCAWG [1]) necessitate all involved parties to exchange individual patient data and perforin all analysis locally, or use a trusted server for maintaining all data to perform analysis in a single site (e.g. the Cancer Genome Collaboratory [2]). Since both approaches involve sharing genomic sequence data - which is typically not feasible due to privacy issues, collaborative data analysis remains to be a rarity in genomic medicine.