Effect of liquid crystal properties on the hemocompatibility of polymer/liquid crystal composite membranes

摘要

As we have known, the inner surface of vessels seems very smoothy macroscopically and is covered with a liquid matrix which embed all kinds of sacchprotein and sacchlipids. The sacchprotein and sacchlipids molecules are always movement in the liquid matrix and the inner membrane of vessels is a macroscopically smooth and microscopically phase-separating structure. In our opion, these may be main reason why the vessel has an excellent anticoagulability. In addition, it is widely recognized that the cell membrane is the bilayer membrane composed by lipids and protein. Lipids molecules from double molecule membrane, its hydrophilic groups face outside. This kind of molecular orientation is very similar with lamellar micelle of lyotropic liquid crystal and nematic phase of thermotropic liquid crystal. The protein molecules form two protein layers after absorbed on the hydrophilic groups. It is common knowledge that there are many other liquid crystal phenomena in biological system, such as sterone hormone, marrow phospholipid in neurotissue. mussel fiber, lipids in connective tissue and so on. Although liquid crystal phenomena in biosystem had already been discovered and the research on biomaterials had been highlighted by scientists around the world, it is'nt found to utilize artifitial liqudi crystal to improve the hemocompatibility of biomaterials till ou rpaper written.