Brownian Dynamics Simulation for Electrophoretic Migration of DNA Nanostructures in a 2D Anisotropic Nanosieving Structure

摘要

This study aims to establish a simulation scheme for microchip-base size-separation of DNA nanostructures, which has great potential in playing important role as a functional nanoscale building block in many applications such as MEMS. A Brownian dynamics simulation for the electrophoretic migration of DNA nanostructure with a cylinder-base rigid-body in a micro-fabricated sieving structure was proposed. We checked the validity by comparing the simulated results with reported result for short dsDNA fragments. This simulation method will be exploited to understand parameter dependency of size-separation of DNA origami in ANA in the future.