Co-registering pre- and intra- operative MR data is an important yet challenging problem due to different acquisition parameters, resolutions, and plane orientations. Despite its importance, previous approaches are often computationally intensive and thus cannot be employed in real-time. In this paper, a novel three-step approach is proposed to dynamically register pre-operative 4D MR data with intra-operative 2D RT-MRI to guide intracardiac procedures. Specifically, a novel preparatory step, executed in the pre-operative phase, is introduced to generate bridging information that can be used to significantly speed up the on-the-fly registration in the intraoperative procedure. Our experimental results demonstrate an accuracy of 0.42mm and a processing speed of 26 FPS of the proposed approach on an off-the-shelf PC. This approach, is in particularly developed for performing intra-cardiac procedures with real-time MR guidance.
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