MATHEMATICAL MODELLING OF SYSTEMIC CIRCULATION AND HEAT EXCHANGE IN WHOLE BODY HYPERTHERMIA (43-44℃)

摘要

Many experimental and clinical trials showed a high efficacy of whole body hyperthermia (43-44℃) (WBH) in treatment of malignant tumors and in some viral diseases including HIV/AIDS. However a widespread clinical application of WBH remains difficult due to weakly correctable circulation disturbances. The aim of current research is to describe structural connections between the organs during WBH (43-44℃), and find the way to stabilize blood circulation. Current research formulates model requirements for blood circulation changes, and shows interconnections between the models of circulation and heat transfer. Potentialities of circuit theory allow measuring of some parameters (thermal capacity and thermal conductivity of organs) in the beginning of WBH procedure when circulation is stable. The usage of the obtained results allows predicting blood circulation disorder and prevention their when rising the body temperature over 42℃. Thus it can be use for temperature calculation, increase of efficacy and safety of hyperthermia. The equations set for the description of heat exchange between the heat-carrier (hot water) and an organism are created as an example realization of the approach to this problem. The numerical modelling in Matlab, toolbox Simulink is executed. Results of modelling are displayed.