Inflammation-modulating biomaterial impacts neutrophil-monocyte juxacrine and paracrine regulation

摘要

The incorporation of ECM-derived component gelatin to a PEG matrix resulted in an effected inflammation-modulating construct that mediated normal inflammatory response that quickly attenuated with more pro-healing MC phenotype. This minimalistic but yet robust material design bypass the complexity of employing biomolecules such as IL4 in regulating the host inflammatory response.