Sol-Gel Dip-Coating for Immobilization of Poly (ε-lysine) Dendrons on Biomaterials Surfaces for Regenerative Medicine Applications

摘要

The aim of this research was to produce and characterize a new method to modify biomaterial surfaces that included sol-gel technique and dendron synthesis. The principle was to match features of sol-gel coating with those of the dendrons, to obtain a functionalized biocompatible coating. The research has highlighted that this aim could be easily achieved: dendrons can be functionalized with any sort of moiety and can increase the surface to fiinctionalize due to their hyperbranched structure. In addition, sol-gel was proven to provide a stable coating exhibiting functional groups on the surface. In this study it has been demonstrated that the different peptide sequences used truly induce a different cell response. Therefore this approach could be suitable for many regenerative medicine approaches e.g. regeneration of bone for better implant integration or for regeneration of tissue-for the treatment of ischemic injury.