Incorporation of RANKL Promotes Osteoclast Formation and Osteoclast Activity on β-TCP Ceramics

摘要

The technique by which RANKL is immobilized on the CaP ceramics plays a key role in the support of osteoclast development and activation. With the co-precipitation technique, the differentiation of osteoclasts is initiated due to a residual passive release of incorporated RANKL. Once formed, osteoclasts mediate the release of RANKL, thereby perpetuing their differentiation and activation, which results in a stimulation of cell-mediated CaP resorption.