ANALYTICAL REQUIREMENTS FOR DETERMINATION OF NON DIOXIN-LIKE PCBS IN FOOD (PCB # 28, 52, 101, 138, 153, 180)

摘要

The EU Commission has initiated steps to set maximum levels for non dioxin-like PCBs expressed as sum of the concentrations of six indicator PCBs (PCB 28, PCB 52, PCB 101, PCB 138, PCB 153 and PCB 180) in certain food samples. Therefore, the EU Community Reference Laboratory (CRL) for Dioxins and PCBs in Feed and Food was asked by the EU Commission to develop a working document in cooperation with the network of National Reference Laboratories (NRLs) of the EU Member States containing criteria for the analysis of nondioxinlike PCBs (ndl-PCBs) as basis for possible future EU legislation. This working document proposes criteria for analytical methods for determination of PCB concentrations for control of the maximum levels under discussion (= levels of interest). The following aspects are covered: 1. Applicable detection methods, 2. Identification and confirmation of analytes of interest; 3. Demonstration of performance of method; 4. Limit of quantification; 5. Quality control; 6. Control of recoveries; 7. Requirements for laboratories; 8. Upper bound calculation; 9. Criteria for the sum of the six indicator PCBs at the level of interest (Trueness - 30 to + 30 %; Intermediate precision (RSD%) ≤ 20 %; Difference between upper and lower bound calculation ≤ 20 %).