MONO-ORTHO AND DI-ORTHO SUBSTITUTED PCB CONGENERS AND TYPE 2 DIABETES IN THE ANNISTON COMMUNITY HEALTH SURVEY

摘要

Associations between the mono-ortho and di-ortho substituted polychlorinated biphenyls (PCBs) and the prevalence of type 2 diabetes were investigated in adult participants of the cross-sectional community study in Anniston, Alabama, where PCBs were produced between 1929 and 1972. Among study participants with PCB measurements, 205 were classified as having diabetes, 169 as having pre-diabetes and 392 were classified as not having diabetes. We excluded participants with pre-diabetes from the statistical analyses in this study. The median for the sum of mono-ortho PCBs was 1.07 ng/g whole weight for individuals with diabetes and 0.58 ng/g whole weight for those without diabetes. Similarly, in those with diabetes the median for di-ortho PCBs was higher than for those without diabetes (5.20 vs 3.43 ng/g whole weight). We found strong statistically significant associations between diabetes and the sum of mono-ortho PCBs for the second, third and fourth quartiles, relative to the first quartile, after adjustment for the diabetes risk factors in participants less than 55 years of age (OR=3.55 for the second, OR=2.66 for the third, and OR=4.16 for the fourth quartile). Similar, but somewhat weaker associations, were also observed for the di-ortho PCBs for the third and fourth quartiles (OR=1.95 and OR=3.19, respectively).