Organofluorine Chemistry at the Biomedical Interface: A Case Study on Fluoro-Taxoid Anticancer Agents

摘要

New and effective biochemical tools as well as medicinal and therapeutic agents have been successfully developed through strategic incorporation of fluorine(s) based on the rational design by taking into account the special properties of fluorine. Fluorinated analogues of biologically active molecules can also serve as excellent probes for the investigation of biochemical mechanisms. ~(19)F-NMR can provide unique and powerful tools for the structural and mechanistic investigations in chemical biology. This article describes our recent studies on the use of fluorine in the medicinal chemistry and chemical biology of taxane anticancer agents, exploiting the unique nature of this element, as a showcase of the "current fluoroorganic chemistry" at the biomedical interface.