Thermodynamic Advantage of Ligand-Polyrotaxane Conjugates on Multivalent Interaction

摘要

Saccharide, one of the ligands for targeting, insaccharide-polyrotaxane conjugates could easily diffusein buffers via sliding and rotational motion ofα-cyclodextrins (α-CDs) along a poly(ethylene glycol)(PEG) chain. Such a high mobility of saccharide groupsin the conjugate can contribute to preserving orderedstructure of the bulk water clusters. The associationconstant (Ka) between the conjugate and concanavalinA (Con A) was 6 orders of magnitude. The features ofhigh mobility of the ligands and preserving the waterclusters led to gaining a large negative enthalpy.Therefore, the supramolecular motion of thepolyrotaxane is thermodynamically favorable formultivalent interaction in biological systems.