Micelles as Carriers for Poorly Soluble Drugs: Preparation and Anticancer Activity In Vitroof Paclitaxel in Mixed Micelles of PEG-PE and Positively Charged Lipids

摘要

Mixed micelles (MM) consisting of poly (ethylenernglycol)-phosphatidylethanolamine conjugates (PEGPE)rnand cationic Lipofectin? lipids (LL) and loadedrnwith paclitaxel (MM-PT) were prepared. The averagernsize of such micelles was ca. 98 nm, zeta-potentialrnca. -6 mV, and paclitaxel content ca. 4 wt %. In vitrorncytotoxicity of MM-P was significantly greater thanrnthat of free paclitaxel (PT) or paclitaxel in LL-freernPEG-PE micelles (M-PT). MM seem to be able tornescape from endosomes and deliver the drug into therncytoplasm of cancer cells.