IN VITRO CHARACTERIZATION OF TOLMETIN SODIUM LOADEDORAL MICROSPHERES PREPARED BY USING pH-DEPENDENT AND pH-INDEPENDENTEUDRAGIT POLYMERS

摘要

As with most non-steroidal antiinflammatory drugsrn(NSAIDs), the side effects of tolmetin sodium result inrngastro-intestinal mucosae irritation and possiblerngastric ulcerative symptoms (1,2). For this reason,rntolmetin sodium microspheres were prepared for oralrnadministration using various Eudragit polymersrn(polymethacrylates) by emulsion-solvent diffusion andrnw/o/w multiple emulsion technique. After preparation,rnthe microparticles were characterized and in vitrornrelease of the formulations were evaluated.