POLYMERIC DELIVERY SYSTEMS FOR RIBOZYMES. I:Nanoparticle Formation by Self-Assembly of Ribozymes with PEG-b-Poly(L-lysine)

机译：核酶的聚合物输送系统。 I：通过核糖酶与PEG-b-聚（L-赖氨酸）的自组装形成纳米颗粒

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Aiming to develop polymeric delivery vehicles forrnribozymes, we synthesized PEG-b-Poly(L-lysine).rnThe diameter of nanoparticles made of PEG-b-rnPoly(L-lysine) and ribozymes was about 100 nm in anrneffective diameter as measured by DLS.rnElectrophoresis results have confirmed that PEG-b-rnPoly(L-lysine) protect ribozymes from Rnase inrnbiological fluids by forming stable complexes withrnribozymes.

机译：为了开发用于核糖核酸酶的聚合物递送载体，我们合成了PEG-b-聚（L-赖氨酸）。rnDLS测量的由PEG-b-rnPoly（L-赖氨酸）和核酶制成的纳米颗粒的有效直径约为100 nm。电泳结果证实PEG-b-rnPoly（L-赖氨酸）通过与核糖酶形成稳定的复合物来保护核酶免受Rnase微生物液的侵害。

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来源
《Controlled Release Society 31st annual meeting transactions: abstracts》|2004年|1-2|共2页
会议地点 Honolulu HI(US)
作者
Jae Hyun Jeong; Yong Woo Cho; Kinam Park; Jong-Duk Kim;
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作者单位

Dept. of Chemical Biomolecular Eng., CUPS, KAIST, Daejeon, Republic of Korea JJHyun@kaist.ac.kr;

Akina Inc., West Lafayette, IN 47906, U.S.A.;

Dept. of Pharmaceutics Biomedical Eng., Purdue University, West Lafayette, U.S.A.;

Dept. of Chemical Biomolecular Eng., CUPS, KAIST, Daejeon, Republic of Korea;

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原文格式 PDF
正文语种 eng
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关键词
Ribozyme; poly(L-lysine); nanoparticle;

机译：核酶;聚（L-赖氨酸）;纳米粒子;

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专利

1. The cellular delivery of antisense oligonucleotides and ribozymes. [J] . Hughes MD, Hussain M, Nawaz Q, Drug discovery today . 2001,第6期

机译：反义寡核苷酸和核酶的细胞递送。
2. Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers. [J] . Toncheva V, Wolfert MA, Dash PR, Biochimica et biophysica acta: international journal of biochemistry and biophysics . 1998,第3期

机译：通过与亲水聚合物接枝的聚（L-赖氨酸）DNA自组装形成的新型基因传递载体。
3. Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers [J] . Veska Toncheva, Margreet A. Wolfert, Philip R. Dash, Biochimica et Biophysica Acta. General Subjects . 1998,第3期

机译：通过与亲水聚合物接枝的聚（L-赖氨酸）DNA自组装形成的新型基因传递载体
4. POLYMERIC DELIVERY SYSTEMS FOR RIBOZYMES. I: Nanoparticle Formation by Self-Assembly of Ribozymes with PEG-b-Poly(L-lysine) [C] . Controlled Release Society annual meeting . 2004

机译：用于核酶的聚合物递送系统。 I：通过用PEG-B-聚（L-赖氨酸）的核酶自组装形成纳米粒子形成
5. Self-assembly polymeric nanoparticles composed of polymers crosslinked with transition metals for use in drug delivery. [D] . Nguyen, Duong Thuy. 2015

机译：由与过渡金属交联的聚合物组成的自组装聚合物纳米颗粒，用于药物输送。
6. Hydrophobic Drug-Triggered Self-Assembly of Nanoparticlesfrom Silk-Elastin-Like Protein Polymers for Drug Delivery [O] . Xiao-Xia Xia, †, Ming Wang, -1

机译：疏水性药物触发的纳米粒子自组装像丝绸-弹性蛋白蛋白聚合物中的药物
7. Functional Nanocarriers for Drug Delivery by Surface Engineering of Polymeric Nanoparticle Post-Polymerization-Induced Self-Assembly [O] . Heba Asem, Wenyi Zheng, Fritjof Nilsson, 2020

机译：聚合物纳米粒子后聚合纳米粒子后表面工程递送的功能纳米载体

POLYMERIC DELIVERY SYSTEMS FOR RIBOZYMES. I:Nanoparticle Formation by Self-Assembly of Ribozymes with PEG-b-Poly(L-lysine)

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