Quantification Of The Cutaneous Betamethasone-17-valerate And Methyl NicotinatePenetration According To The FDA Guidance 'Topical Dermatologic Corticosteroids'

摘要

Drug penetration experiments with betamethasone-rn17-valerate and methyl nicotinate inrntwo different vehicles were performed accordingrnto the FDA Guidance “Topical DermatologicrnCorticosteroids: In vivo bioequivalence”. Anrnopen two-compartment model for betamethasone-rn17-valerate and an open one-compartmentrnmodel for methyl nicotinate was found tornbe adequate for characterization of the responsernvs. time profiles.