BIOSENSORS: MAGNETORESISTIVE DETECTION OF FLOWING AND IMMOBILIZED ASSAY LABELS

摘要

Magnetic nanoparticles are used in many biochemical assays as labels for concentration, manipulation and, more recently, detection. Typically one attaches the magnetic particles to the biochemical species of interest (target) using a chemically specific binding interaction. Once bound, the labels enable the manipulation of the target species through the application of magnetic forces. Spintronic sensors, specifically Giant Magnetoresistive (GMR) and Spin Dependent Tunneling (SDT), sensors have been developed to detect and quantify labels in two main formats: flowing in a microfluidic channel, and immobilized labels on a chip surface. Designs and data for these two types of assays will be presented.