LABEL-FREE DIRECT DETECTION OF SINGLE OLIGONUCLEOTIDE AND ANTIBODY INTERACTIONS WITH A NANOTRANSISTOR

摘要

The pharmacogenomic paradigm of "personalized medicine" promises to provide more effective, more efficient medical care that is tailored to the physiological idiosyncrasies of each patient. These differences are based on each persons genetic and proteomic makeup, in ways that are yet to be fully understood. A major bottleneck to uncovering this information is the complexity and expense of current technologies for studying biological interactions. Nanotechnology offers tools that provide molecular-level information by coupling the biology to an electronic signal. Described in this paper are simplified bioassays for exploring genetic and proteomic binding using "chemically gated" single electron transistors.