Dual polarisation interferometry for real-time, label-free detection of interaction of mercury(Ⅱ) with mercury-specific oligonucleotides

摘要

A real-time, label-free dual polarisation interferometry technique was used to investigate the interaction of Hg~(2+) with a 21-mer T-rich oligonucleotide and further construct a Hg~(2+) biosensor based on thymine-Hg~(2+)-thymine coordination chemistry.