Quantifying Permeability of Glucose in Normal and Atherosclerotic Pig Aorta in vitro using Optical Coherence Tomography

摘要

High in-depth resolution imaging, such as Optical Coherence Tomography, could be the next frontier in noninvasive quantification of diffusion in epithelial tissues. In this study we employed OCT in a method that could help differentiate various forms of atherosclerosis and distinguish between normal and diseased tissue. The diffusion of glucose solution in normal and diseased pig aorta in vitro was monitored and the permeability coefficient was calculated. The results suggest that this OCT method may have high potential for early detection of tissue abnormalities while used in diffusion studies.