Interaction of Few Molecular Motors Transporting One Cargo Along Filament

摘要

Mathematical model of organelle transport by few molecular motors along filament is presented. Each motor is described as mechanochemical system, which consists of 3 elastically coupled Brownian particles and can be in different intrinsic states, jumping from one discrete filament bound site to other. Rigid or elastic coupling between motors and "cargo" are considered. Asymptotic analysis of organelle movement is performed and macroscopic parameters (average velocity and effective diffusion coefficient) are calculated.