Development of real-time multimodal OCT with manual operation capabilities and emergence of its applications in clinical practice

摘要

We report realizations of OCT combining conventional structural imaging, polarization-sensitive one, as well asallowing for real-time angiographic, elastographic and lymphangiographic modalities with manual-operation capabilities.Among the main features of the developed device one can point out on-flight imaging of microvascular network withfeedback for clinicians when performing angiography; in elastography - robust "vector" method of interframe phasevariationgradient estimation and stiffness quantification using reference silicone layers; lymphangiography utilizingpixel statistics beyond conventional amplitude thresholding, etc. These capabilities are ensured by the developed opticalschemes of the probe, signal receiving parts, as well as computationally efficient signal processing methods. Examples ofthe developed device usage in preclinical and clinical applications are discussed (efficient criteria for PDT success;angiographic monitoring of complications during radiotherapy; elastographic classification of tumor and non-tumorregions; detailed imaging of fairly rapid transient and slowly varying deformations in laser-assisted reshaping ofcollagenous tissues; lymphangiography-based diagnostics in gynecology; otolaryngologic applications for diagnosinginner ear diseases, etc.)