With the development of modern pharmaceutics, various good prerequisites are supplied for controlled-release dosage forms of TCM. Osmotic pump controlled release preparation is one of the most ideal preparations in controlled-releasing effect and has achieved the world advanced level because of its many advantages. Jingzhiguanxin prescription is an effective TCMCR, with improving blood circle and clearing up silt in the body, composed of "danshen", "chishao", "chuanxiong", "honghua" and "jiangxiang". Most Chinese medicines are administered orally as decoctions or tablets in clinics, in which the composite formulae will isochronous release and produce a synergistic effect or antagonistic action. So it is not enough that only one maker compound is studied. In this paper, three maker compounds, which represent three main drugs made of Jingzhiguanxin prescription, were studied. It is expected that three maker compound could isochronous release and produced a synergistic effect or antagonistic action.
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