Chemical Syntheses of Hyaluronic Acid Oligosaccharides

摘要

The increasing recognition of important biological functions of hyaluronic acid oligosaccharides (sHA) has led to developments of new methodologies for sHA syntheses. Herein, we provide an overview of chemical approaches for assembling these oligosaccharides. Compared with traditional methods, our iterative one-pot strategy provided a new platform for rapid assembly of sHA without resorting to multiple protective group manipulations, anomeric adjustments or intermediate purifications. We expect that the continual development of chemical synthetic methodologies of sHA will provide a facile access to structurally well defined sHA derivatives that will greatly facilitate structure-activity relationship studies.