Production of NSAID pharmaceutical molecular liquids via RESS processing

摘要

We report the production of pharmaceutical molecular clusters of most commonly implemented and prominent drug molecules such as ibuprofen and naproxen, via Rapid Expansion of Supercritical Solution (RESS) processing under mild conditions. These drug molecular clusters were first trapped in "dry ice" and subsequently solubilized in DI water under ambient conditions. These solutions are found to be stable over a period of several weeks. Drop casting and ambient drying of these solutions on a silicon substrate resulted in stable, viscous liquid films. Optical and electron microscopy showed typical liquid like behavior of these drop casted films. In-vitro cell viability studies, clearly demonstrated that the water-solubilized ibuprofen and naproxen exhibit similar cytotoxicity to the as received, raw drug powders thus retaining their original potency.